CategoriesSupplements Vitamin C

Liposomal Vitamin C: Discover How It Works and 6 Reasons It’s Superior to Traditional Vitamin C

liposomal Vitamin C

What is Liposomal Vitamin C?

Liposomal vitamin C is a specially formulated type of vitamin C supplement designed for enhanced absorption and bioavailability in the body. By enclosing vitamin C in liposomes – phospholipid spheres that act as delivery vehicles – more of the vitamin C can successfully reach the bloodstream to exert its beneficial effects.

What are Liposomes?

Liposomes are spherical lipid vesicles made up of phospholipids, the primary components of cell membranes. The liposome structure is a lipid bilayer membrane surrounding an aqueous core.

Phospholipids contain a hydrophilic (water-loving) head and a hydrophobic (water-hating) tail. When phospholipids are immersed in water, the hydrophobic tails face inward towards each other while the hydrophilic heads face outward towards the water. This forms the spherical shell structure of the liposomes.

Liposomal supplements benefits

  • Biocompatible and biodegradable – made of compounds found naturally in the body
  • Protect encapsulated compounds from degradation
  • Enhance absorption by fusing with cell membranes
  • Allow for targeted intracellular delivery
  • Provide sustained release of encapsulated agents
  • Encapsulating Vitamin C

In liposomal vitamin C, the vitamin C molecules are encapsulated within the water-based core of the liposomes. The phospholipid bilayer surrounding the vitamin C protects it from destruction by stomach acid and digestive enzymes.

Without this liposome shield, much of the vitamin C from regular supplements gets broken down before being absorbed after oral ingestion. But the liposome carrier allows the vitamin C to pass through the gut lining and into the bloodstream intact.

The liposomes also facilitate delivery of the vitamin C directly inside cells for optimal antioxidant effects. As well as provide a slow sustained release of vitamin C over time.

How Does Liposomal Vitamin C Work?

Liposomal vitamin C is designed to overcome the normal barriers that limit vitamin C absorption and bioavailability when taken orally. The liposome carrier helps shield and transport vitamin C through the digestive system and into circulation more efficiently.

There are four main barriers that liposomes help vitamin C overcome:

Gastric acidity – The acidic environment of the stomach can degrade a significant portion of vitamin C before it gets absorbed. The liposome sphere protects the vitamin C inside from acid degradation.

Intestinal mucosal lining – Transport of vitamin C across the intestinal lining is limited by saturation of the vitamin C transport proteins. Liposomal vitamin C in contrast can diffuse passively across the intestinal barrier without needing protein transporters. This allows for greater absorption.

Unwanted protein binding – Vitamin C tends to bind with proteins in the blood, limiting its bioavailability. The liposomal capsule prevents this premature protein binding, keeping more vitamin C free and active.

Enzymatic attacks – There are various enzymes in the blood that can degrade vitamin C. Again, the liposome bilayer provides insulation from these enzymes.

The lipid bilayer membrane protects the vitamin C from severe gastric acidic degradation in the stomach. The small size and lipid solubility of the liposomes allows easy absorption of the vitamin C complexes across the intestinal barrier and into circulation by diffusion rather than active transport.

Bypassing protein transport prevents saturation limits and allows massive vitamin C doses to be absorbed. Liposomes prevent unwanted vitamin C binding to blood proteins and shield them from degrading enzymes.

Moreover, liposomes can fuse with cell membranes for targeted vitamin C delivery directly inside cells. They provide controlled slow release of vitamin C over an extended period to maintain therapeutic levels

Benefits of Liposomal Vitamin C

The liposomal delivery system results in substantially elevated vitamin C levels in the body compared to regular vitamin C, the health benefits of vitamin C are enhanced.

1. Powerful Antioxidant Effects

Vitamin C is a potent antioxidant that can neutralize free radicals and prevent oxidative damage to cells and tissues throughout the body. Oxidative stress caused by free radicals contributes to aging and many disease processes. By boosting antioxidant status, liposomal vitamin C helps:

  • Reduce cellular and DNA damage
  • Combat inflammation and chronic disease
  • Support healthy aging and longevity
  • Prevent oxidative damage related to pollution and poor lifestyle habits

2. Immune Support

Vitamin C plays a central role in immune function. Among its immune-boosting effects, vitamin C helps:

  • Increase production of white blood cells
  • Boost phagocytic activity to clear pathogens
  • Increase lymphocyte proliferation and differentiation
  • Enhance antibody production and activity
  • Protect immune cells from oxidative damage

By delivering higher vitamin C levels to immune system cells, liposomal C supplements can strengthen the body’s defenses against pathogens and prevent infections.

3. Collagen Production

Vitamin C is required to manufacture collagen, the most abundant protein in the body. Collagen provides the foundation for skin, bones, joints, blood vessels, tendons, gums, teeth, and intervertebral discs. The enhanced vitamin C absorption from liposomal delivery can support optimal collagen synthesis to keep these tissues healthy, improving outcomes like:

  • Reduction in skin wrinkling and sagging
  • Decreased joint pain and disability
  • Faster wound healing and recovery from injury
  • Prevention of easy bruising and bleeding gums

4. Heart Health

Emerging evidence indicates vitamin C helps protect cardiovascular health in several ways. Liposomal vitamin C may:

  • Lower blood pressure by reducing inflammation and artery stiffness
  • Increase HDL “good” cholesterol while lowering LDL “bad” cholesterol
  • Prevent LDL cholesterol from oxidizing and damaging blood vessels
  • Improve blood vessel relaxation and endothelial function
  • Reduce risk of stroke, heart attack, and peripheral artery disease

5. Anti-Cancer Effects

While more research is needed, certain studies suggest vitamin C may have anti-cancer properties by inhibiting tumor growth. Proposed mechanisms include:

  • Inducing apoptosis (programmed cell death) in cancer cells
  • Blocking cancer cell metabolism
  • Reducing inflammation and oxidative damage that triggers cancer
  • Enhancing immune defenses against early tumors
  • Minimizing side effects of chemotherapy/radiation therapy

The improved vitamin C delivery from liposomal encapsulation may provide enhanced protective effects against cancer development and progression.

6. Respiratory Health

The antioxidant and anti-inflammatory properties of vitamin C promote respiratory health. Liposomal vitamin C may help:

  • Alleviate allergy and asthma symptoms
  • Reduce histamine levels and upper respiratory tract inflammation
  • Protect lungs from oxidative damage caused by pollution, smoking, infections
  • Shorten duration and severity of cold/flu
  • Reduce risk of respiratory tract infections like pneumonia

7. Mood and Psychological Well-Being

Higher vitamin C levels in the brain can improve neurotransmitter synthesis and nervous system functioning. Liposomal vitamin C supplements may help:

  • Reduce anxiety, depression, and stress
  • Boost mood, positivity, motivation, and energy
  • Improve sleep quality and duration
  • Enhance cognitive performance and memory
  • Slow age-related mental decline

8. Other Health Benefits

Research shows vitamin C has numerous other benefits throughout the body. Liposomal encapsulation can enhance these effects:

  • Increase iron absorption to prevent anemia
  • Support bone density and reduce fracture risk
  • Maintain healthy gums and prevent periodontal disease
  • Aid wound healing and minimize scarring
  • Regulate blood sugar and insulin sensitivity

Advantages of Liposomal Vitamin C Over Conventional Forms

Liposomal vitamin C has significant advantages over regular vitamin C supplements in terms of absorption, bioavailability, efficacy, and tolerability. The lipid encapsulation protects the vitamin C and facilitates better uptake and targeted delivery. 

1. Absorption

Regular vitamin C is water-soluble while liposomal vitamin C is lipid-soluble. The water solubility makes it difficult for conventional vitamin C to cross lipid cell membranes. Liposomal vitamin C more easily crosses intestinal and cell membranes by diffusion to get absorbed.

2. Bioavailability

Due to the limitations of intestinal active transport, only a fraction of regular vitamin C gets absorbed and utilized by the body. Studies show liposomal vitamin C has a bioavailability of 90% compared to only 10-20% for traditional oral vitamin C.

The liposomal spheres protect vitamin C from acid and enzyme degradation, allowing more to reach circulation intact. The smaller size and lipid solubility also enhances tissue and cell penetration. Overall, far more of the vitamin C content gets put to use.

3. Efficacy

The dramatically increased bioavailability translates to enhanced efficacy. More vitamin C is available to exert antioxidant, immune boosting, collagen production, cardiovascular, and other benefits throughout the body.

Targeted intracellular delivery further improves efficacy. The vitamin C can be released within cells at sites of action. Lower doses produce optimal effects.

4. Tolerability

The high acidity and osmotic effect of regular vitamin C often causes GI side effects like diarrhea, nausea, and stomach pain at higher doses. With liposomal vitamin C, the phospholipid membrane cushions the acidity.

By preventing vitamin C from dumping into the intestines, liposomes minimize osmotic loose stools. Vitamin C is steadily released over time rather than overloaded into the system.

5. Cost

Despite having a higher upfront price, liposomal vitamin C provides more value and savings long-term. The boosted absorption and efficacy mean fewer pills are needed compared to conventional vitamin C. Dosages can often be cut in half.

6. Safety

Liposomal encapsulation avoids the use of problematic additives found in some regular vitamin C products, like artificial fillers, flavors, and sweeteners. Clean liposomal products contain pure ingredients.

In summary, liposomal vitamin C offers maximal absorption, effectiveness, tolerability, and purity – making it the ideal delivery method for vitamin C supplementation. When choosing a liposomal C product, quality ingredients, and manufacturing are key to getting the full benefits.

Forms of Vitamin C

The basic forms of liposomal vitamin C include liquid, powder, and capsules. Each form has its own advantages and disadvantages.

1. Liquid liposomal vitamin C

Liquid liposomal vitamin C consists of water mixed with vitamin C and phospholipids. The liquid ensures the vitamin C and phospholipids self-assemble into liposomes. Liquid Vitamin C for adults may come in dropper bottles or single-serve liquid packets. 

The main benefit of liquids is convenience – they are ready to take orally or mix into drinks. Drawbacks are potential leaking during transport and shorter shelf life once opened compared to powders and capsules.

2. Powdered liposomal vitamin C

Powdered liposomal vitamin C is essentially a dehydrated version where the water content has been removed. Before taking, the consumer must reconstitute the powder in water or juice. This increases the shelf life and allows for convenient on-the-go dosing in individual packets. 

However, it does require an extra preparation step. The powders often contain flavoring agents to mask the sour taste of vitamin C.

3. Liposomal Vitamin C Capsule

Capsule forms enclose the liposomal vitamin C liquid or powder in either a gelatin or vegetarian capsule. This eliminates taste and convenience issues. 

However, the gelatin capsule may interfere with liposome integrity upon digestion. Capsules also contain fewer phospholipids per dose compared to straight liquids and powders.

Types of Liposomal Vitamin C 

There are two main types of vitamin C used in liposomal products:

1. Mineral ascorbate form of vitamin C

Sodium ascorbate is a mineral ascorbate form of vitamin C bound to sodium. It is more alkaline and therefore gentler on the stomach than regular ascorbic acid. Many people find sodium ascorbate easier to tolerate, especially at higher doses. It provides all the benefits of vitamin C in a well-absorbed form.

2. Ascorbic acid form

Ascorbic acid is the simplest most common type of vitamin C. It is relatively inexpensive to manufacture and widely available. Ascorbic acid has a low pH and can be irritating to the GI tract in large doses. However, the acidic nature helps dissolve the phospholipids when forming liposomes.

3. Combination

Some liposomal vitamin C supplements use a combination of sodium ascorbate and ascorbic acid to provide both forms. Sodium ascorbate is optimal for sensitive stomachs while ascorbic acid facilitates liposome formation.

4. Phospholipid Sources

The phospholipids that make up the liposome spheres usually come from purified plant sources like soy or sunflowers. The main types used are phosphatidylcholine and phosphatidylethanolamine. These are essentially vitamin C without ascorbic acid.

Phosphatidylcholine is a key component of cell membranes and the primary phospholipid used in liposomal supplements. It helps form bilayer liposome structures that efficiently encapsulate vitamin C.

Phosphatidylethanolamine is also naturally found in cell membranes. Some research indicates combining PE with PC improves liposomal membrane integrity and absorption.

Quality liposomal C products will use highly purified phospholipid extracts to avoid contaminants. Some formulas combine both phosphatidylcholine and phosphatidylethanolamine.

5. Additional Ingredients

Other substances added to liposomal vitamin C aim to improve the product’s absorption, shelf life, taste, and user experience:

MCT oil – Enhances vitamin C absorption and provides fatty acids

Flavors – Mask the sour taste of vitamin C (citrus flavors, stevia)

Preservatives – Prolong shelf life (potassium sorbate)

Sweeteners – Improve palatability (stevia, monk fruit)

Coloring agents – Provide a light orange hue

Ideally, liposomal vitamin C should not contain unnecessary fillers, allergens, artificial colors or sweeteners. Clean products focus on high quality vitamin C and phospholipids.

What to Look for in a Liposomal Vitamin C Supplement

When evaluating liposomal vitamin C supplements, here are some key factors to look for:

  • High-quality vitamin C – Should use sodium ascorbate, ascorbic acid, or a combination
  • Ample vitamin C content – At least 500mg per serving is recommended
  • High-quality phospholipids – Phosphatidylcholine and/or phosphatidylethanolamine
  • Clean ingredients – Free of unnecessary fillers, additives, preservatives
  • Manufacturer reputation – Look for good manufacturing practices
  • Third-party testing – Independent lab testing for purity and potency
  • Positive reviews – Customer satisfaction and experience
  • Reasonable price – Balance of quality and affordability

Buying a high-quality product from a reputable manufacturer will provide the best results in terms of absorption, efficacy, safety, and value.

How to Take Liposomal Vitamin C Supplements

Here are some guidelines on using liposomal vitamin C supplements:


Depends on individual needs and health goals. The general supplement dose is 500-2,000mg per day. Higher short-term doses of up to 10,000mg can be used for immune support during illness. Start low and increase gradually.


Can be taken once daily or divided into multiple doses throughout the day. Multiple smaller doses may help maintain steadier vitamin C levels.

When to take

For maximal absorption, take on an empty stomach at least 30 minutes before eating food.

How to take 

Liquid formulas can be held under the tongue briefly before swallowing. Powders can be mixed into water or juice. Capsules should be taken with a full glass of water.


Take regularly to maintain vitamin C status in the body rather than relying on occasional large doses.

Side Effects and Precautions

Liposomal vitamin C is generally well tolerated, especially at moderate doses. However, very high doses may cause temporary side effects in some individuals, including:

  • Nausea, diarrhea, abdominal cramps – High doses can draw water into the intestines
  • Headache, fatigue, insomnia – Excessively high doses may disrupt sleep
  • Kidney stones – Increased risk in those already prone to developing them

To avoid potential side effects:

  • Start with a low dose and slowly increase it to find the optimal dosage
  • Stay below 10,000 mg per day unless medically supervised
  • Reduce dosage if any concerning symptoms develop
  • Drink adequate water daily while supplementing

Certain individuals should exercise caution with high dose and/or long-term liposomal vitamin C intake:

  • Those with G6PD deficiency – Genetic disorder increasing risk of hemolytic anemia
  • People with a history of kidney stones
  • Individuals with iron overload conditions

Liposomal vitamin C has not been sufficiently studied for safety during pregnancy or breastfeeding, so it is not recommended without medical guidance.

Frequently Asked Questions

Is liposomal vitamin C better than regular vitamin C?

Yes, the liposomal delivery method makes vitamin C far more bioavailable compared to standard vitamin C tablets or powders. Enhanced absorption allows you to fully utilize the vitamin C rather than excreting excess unused vitamin in the urine.

How long does liposomal vitamin C stay in your system?

Due to the sustained release effect, liposomal vitamin C can provide elevated plasma vitamin C levels for 6-8 hours. Regular vitamin C is used up by the body within 2-3 hours.

Where is vitamin C absorbed?

Vitamin C is primarily absorbed in the small intestine. It is transported actively across the intestinal wall into blood circulation via sodium-dependent vitamin C transporters (SVCTs). 

When should I take liposomal vitamin C for best results?

For optimal absorption, it’s best to take liposomal vitamin C on an empty stomach and wait at least 30 minutes before eating food. It can be taken all at once or split into smaller doses throughout the day.

What helps vitamin C absorption?

Taking vitamin C with flavonoids 
Adding iron-rich foods 
Taking with fatty meals 
Avoiding smoking
Splitting doses
Using liposomal vitamin C
Getting adequate zinc
Reducing gut inflammation

Can liposomal vitamin C replace intravenous (IV) vitamin C shots?

For most people, a quality liposomal C supplement can offer similar benefits to IV vitamin C at a much lower cost and inconvenience. However, IV allows extremely high short-term vitamin C levels in the blood that oral forms cannot achieve.

What is the best form of vitamin C?

Here are some of the best forms of vitamin C:
Liposomal Vitamin C: Vitamin C molecules enclosed in phospholipid spheres for enhanced absorption and bioavailability. Avoid gastrointestinal issues.
Sodium Ascorbate: A buffered mineral salt form of vitamin C that is less acidic than ascorbic acid. Easier on sensitive stomachs.
Ascorbic Acid: The basic pure form of vitamin C. Most cost-effective form. Can be harsh on the stomach in large doses.
Ester-C: Vitamin C bound to calcium, threonate, and other nutrients. Touted to be less acidic.
Vitamin C with Bioflavonoids: Bioflavonoids enhance the benefits and absorption of vitamin C. Found together naturally.
Whole Food Vitamin C: Vitamin C derived from whole food sources like camu camu, amla, acerola cherries. Provides cofactors.
For most people, liposomal vitamin C, sodium ascorbate, and plain ascorbic acid provide the best absorption and value. The form can be tailored based on stomach sensitivity and specific needs.

Are there any side effects or safety concerns?

When taken as directed, liposomal vitamin C is very safe for most people. However, very high doses may cause temporary GI upset or headaches in some individuals. Those with certain medical conditions should exercise caution with high dose and long-term use.

Is liposomal vitamin C safe to take when pregnant or breastfeeding?

There is insufficient research on liposomal vitamin C in pregnancy and lactation. It’s best to avoid supplementing with it unless approved by your healthcare provider.

How is liposomal vitamin C manufactured?

It’s made by combining vitamin C and phospholipids like phosphatidylcholine in water, then using methods like sonication or membrane extrusion to form the vitamin C into liposomes surrounded by phospholipid membranes.


Liposomal vitamin C represents an advanced delivery method that can dramatically improve the benefits of vitamin C supplementation. By encapsulating vitamin C within a phospholipid sphere, liposomes protect the vitamin C from destruction and facilitate better absorption, bioavailability, and targeted delivery.

Compared to traditional vitamin C tablets and powders, studies demonstrate substantially higher peak plasma vitamin C levels with liposomal forms. The increased bioavailability enables users to reap more antioxidant, immune-enhancing, collagen-supporting, and other benefits from lower doses.

Liposomal vitamin C comes in liquid, powder, and capsule forms to suit different preferences. When selecting a product, quality ingredients like phospholipid sources and manufacturing processes are important factors for maximal efficacy. While costlier than regular vitamin C, liposomal forms provide greater value through enhanced absorption and controlled release.